Thermo Fisher Scientific ZNF281 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: -

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000
• Publications: -

Product Specifications

Product Specific Information

• Recommended positive control: ZNF281 transfected 293T cell
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression.
ZFP281 interacts with transcription factors such as Sp1 to repress vimentin gene transcription and controls embryonic stem cell pluripotency by directly regulating specific target genes. It physically interacts with transcription factors POU5F1, Sox2, and NANOG.
Gene expression microarray analysis indicates that some ZFP281 target genes are activated while others are repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifunctional roles in regulating gene expression in stem cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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