Thermo Fisher Scientific SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), eFluor 660, eBioscience
인간 SLAM-Associated Protein(SAP)을 인식하는 XLP-1D12 단클론 항체로, eFluor 660 형광체가 결합된 제품입니다. 세포 내 염색 및 유세포 분석에 최적화되어 있으며, 고순도 친화 크로마토그래피 정제 및 안정적 PBS/BSA 저장 조건을 갖습니다.
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Thermo Fisher Scientific SAP (SLAM-Associated Protein) Monoclonal Antibody (XLP-1D12), eFluor 660, eBioscience
Applications
- Intracellular staining
- Flow cytometric analysis
Tested Dilution
- 5 µL (0.03 µg)/test
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | XLP-1D12 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574380 |
Product Specific Information
The monoclonal antibody XLP-1D12 reacts with human SLAM-associated protein (SAP, SH2D1A). SAP is a 15-kDa SH2 domain-containing adaptor protein that recruits Fyn tyrosine kinase upon CD150/SLAM receptor ligation, activating downstream signaling.
SAP is expressed in thymocytes, T cells, NK cells, and NKT cells, and plays a role in follicular T helper cell differentiation, NKT cell development, Th1/Th2 differentiation, and regulation of NK/CD8+ T cell cytotoxicity.
Mutations in SAP lead to X-linked lymphoproliferative (XLP) syndrome, associated with impaired humoral immunity and susceptibility to Epstein-Barr virus infection and lymphoma. SAP has also been linked to autoimmune diseases such as systemic lupus erythematosus.
Applications Reported: Suitable for intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and tested using normal human peripheral blood cells and the Foxp3/Transcription Factor Staining Buffer Set (Product #00-5523-00).
Recommended use: 5 µL (0.03 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Refer to BestProtocols® for detailed staining procedures.
Fluorochrome Information:
eFluor® 660 is a replacement for Alexa Fluor® 647.
- Excitation: 633–647 nm
- Emission: 668 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene encodes a protein crucial for bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule (SLAM) to inhibit SHP-2 recruitment and modulate signal transduction in activated immune cells.
Mutations cause X-linked lymphoproliferative syndrome (Duncan disease), resulting in susceptibility to Epstein-Barr virus infection and lymphoma. Multiple transcript variants exist for this gene.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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