Thermo Fisher Scientific STAT5A Monoclonal Antibody (OTI9F7), TrueMAB
STAT5A 단백질을 검출하기 위한 고특이성 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. Mouse IgG1 형식이며, Lyophilized 형태로 제공. 다양한 종(Dog, Human, Rat)에 반응하며 연구용으로 적합.
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Thermo Fisher Scientific STAT5A Monoclonal Antibody (OTI9F7), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9F7 |
| Immunogen | Full-length human recombinant STAT5A protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
STAT5 alpha belongs to the STAT family of transcription factors. Upon cytokine or growth factor stimulation, STAT proteins are phosphorylated, form dimers, and translocate to the nucleus to act as transcription activators.
STAT5A mediates responses to IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of STAT5A is linked to tumorigenesis in myeloma and lymphoma associated with TEL/JAK2 fusion.
In mice, STAT5A induces BCL2L1/BCL-X(L) expression, suggesting an antiapoptotic role. STAT5A and STAT5B share 96% sequence similarity and are co-expressed in most tissues, with differential mRNA accumulation in muscle and mammary tissues.
STAT5A plays key roles in reproduction, lactation, immune function, and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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