Thermo Fisher Scientific ASGR1 Recombinant Rabbit Monoclonal Antibody (021)
Human ASGPR1 단백질을 인식하는 recombinant rabbit monoclonal antibody입니다. Western blot 및 Immunoprecipitation에 적합하며, 높은 특이성과 재현성을 제공합니다. 보존제가 없는 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 1–4 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 021 |
| Immunogen | Recombinant Human ASGPR1 protein (Gln62–Leu291) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784979 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
This antibody has specificity for Human ASGPR1.
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (~42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues. It is expressed on hepatocytes in a polar manner—present on sinusoidal and lateral plasma membranes but absent on the bile canalicular membrane.
The mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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