Thermo Fisher Scientific Bcl-xL Recombinant Rabbit Monoclonal Antibody (016)
Human BCL2L1/Bcl-XL 단백질에 특이적인 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. WB, ICC/IF, ELISA, IP 등 다양한 응용 가능. 보존제 무첨가로 세포 오염 방지를 위해 sodium azide 추가 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 5 µg |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 016 |
| Immunogen | Recombinant Human BCL2L1/Bcl-XL Protein (Met1–Arg212) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784983 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
This antibody specifically detects Human BCL2L1/Bcl-XL.
Target Information
BCL-XL is a member of the BCL-2 protein family. These proteins form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in diverse cellular activities.
BCL-XL is located at the outer mitochondrial membrane and regulates the opening of the voltage-dependent anion channel (VDAC).
VDAC controls mitochondrial membrane potential and the release of cytochrome C, both key factors in apoptosis.
Two alternatively spliced transcript variants exist:
- The longer isoform acts as an apoptotic inhibitor.
- The shorter isoform acts as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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