Thermo Fisher Scientific Phospho-MST2 (Ser316) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of STK3 only when phosphorylated at Ser316.

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand. STK3 functions as a stress-activated, pro-apoptotic kinase which, upon caspase cleavage, translocates to the nucleus to induce chromatin condensation and DNA fragmentation. It is a key component of the Hippo signaling pathway, crucial for organ size control and tumor suppression by regulating cell proliferation and apoptosis. The pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, activate LATS1/2 with MOB1, leading to phosphorylation and inactivation of YAP1 and WWTR1/TAZ, thus controlling gene expression related to proliferation and cell death. STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.