Thermo Fisher Scientific Phospho-SQSTM1 (Ser266) Polyclonal Antibody

Thermo Fisher Scientific Phospho-SQSTM1 (Ser266) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Species Reactivity

• Human
• Mouse
• Rat

Host / Isotype

• Rabbit / IgG

Class

• Polyclonal

Type

• Antibody

Immunogen

A synthesized peptide derived from human SQSTM1 (Accession Q13501), corresponding to amino acid residues around phosphorylated Ser266.

Conjugate

• Unconjugated

Form

• Liquid

Concentration

• 1 mg/mL

Purification

• Sequential chromatography

Storage Buffer

• PBS, pH 7.4, with 50% glycerol

Contains

• 0.02% sodium azide

Storage Conditions

• −20°C

Shipping Conditions

• Wet ice

RRID

• AB_2817066

Product Specific Information

Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser266.

Target Information

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway.
The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals.
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene.
Mutations in this gene result in sporadic and familial Paget disease of bone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.