Thermo Fisher Scientific CYP2D6 Recombinant Rabbit Monoclonal Antibody (JM44-23)
CYP2D6 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow Cytometry에 사용 가능. 높은 특이성과 일관된 로트 간 재현성을 제공하며, 약물 대사 관련 연구에 적합. 단백질 A로 정제된 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM44-23 |
| Immunogen | Recombinant protein within Human Cytochrome P450 2D6 (aa 301–497) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810012 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Key advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 enzyme superfamily. These monooxygenases catalyze reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids.
CYP2D6 localizes to the endoplasmic reticulum and metabolizes approximately 20% of commonly prescribed drugs, including:
- Debrisoquine (adrenergic-blocking drug)
- Sparteine and propafenone (anti-arrhythmic drugs)
- Amitriptyline (anti-depressant)
The CYP2D6 gene is highly polymorphic, with certain alleles resulting in a poor metabolizer phenotype. It is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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