Thermo Fisher Scientific CYR61 Polyclonal Antibody, DyLight 488
CYR61 단백질을 인식하는 DyLight 488 결합 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 토끼 반응성. 항원 친화 크로마토그래피로 정제. 암, 혈관 생성, 상처 치유 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to the human CYR61 protein sequence (between residues 150–250). |
| Conjugate | DyLight™ 488 |
| Excitation/Emission Max | 492 / 519 nm |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 50 mM sodium borate |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155988 |
Product Specific Information
This antibody is predicted to react with rat and mouse based on 88% sequence homology.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor–inducible immediate-early gene. It associates with the extracellular matrix and connective tissue and belongs to the CCN protein family, which includes connective tissue growth factor (CTGF) and the mouse homolog Fisp12.
As an angiogenic inducer, CYR61 binds to integrin αvβ3, stimulating cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Expression increases during vessel growth, wound healing, and chondrocyte differentiation. CYR61 is also detected in many tumors and acts as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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