Thermo Fisher Scientific CYR61 Polyclonal Antibody, DyLight 550

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100

-

Immunocytochemistry (ICC/IF)

1:10-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rabbit

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to the human CYR61 protein sequence (between residues 150-250). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CYR61,uniProtId:O00622-1,ncbiNodeId:9606,antigenRange:150-250,antigenLength:381,antigenImageFileName:PA5-22766_CYR61_O00622-1_Rabbit.svg,antigenImageFileNamePDP:PA5-22766_CYR61_O00622-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

DyLight™ 550 DyLight™ 550 DyLight™ 550

Excitation/Emission Max

556/570 nm View spectra

Form

Liquid

Concentration

0.58 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

50mM sodium borate

Contains

no preservative

Storage conditions

4° C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11157839

Product Specific Information

This antibody is predicted to react with rat and mouse based on 88% sequence homology.

Target Information

CYR61 is a secreted heparin binding protein, encoded by a growth factor inducible immediate-early gene that associates with the extracellular matrix and connective tissue. CYR61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse CYR61 homolog, Fisp12. As an angiogenic inducer, CYR61 binds to the cell surface receptor integrin alphavbeta3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of CYR61 is elevated during vessel growth, wound healing and chondrocyte differentiation. CYR61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.