Thermo Fisher Scientific ACCN2 Polyclonal Antibody
ACCN2(ASIC1) 단백질을 인식하는 양(IgG) 폴리클로날 항체로, Western blot 및 IHC에 사용 가능. 인간, 생쥐, 랫트에 반응하며, 합성 펩타이드 항원을 이용해 제조됨. PBS 버퍼 내 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular domain of rat ACCN2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and shares 96% identity with human.
- Specificity of this antibody: ASIC1.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels containing intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop with many conserved cysteine residues.
The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. It acts as a cation channel with high affinity for sodium, gated by extracellular protons, and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺ and expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neocortical and allocortical regions, hippocampal formation, cerebellum, and other brain regions.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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