Thermo Fisher Scientific Phospho-ATF4 (Ser245) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100
• Publications: -

Product Specifications

Product Specific Information

A suggested positive control for IHC is human breast carcinoma.

Target Information

This gene encodes a transcription factor originally identified as a mammalian DNA-binding protein that binds a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also characterized as cAMP-response element binding protein 2 (CREB-2).
It belongs to a family of DNA-binding proteins including AP-1, CREBs, and CREB-like proteins. These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.