Thermo Fisher Scientific Phospho-ATF4 (Ser245) Polyclonal Antibody
Human ATF4의 Ser245 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 적용 가능. 고순도 Affinity chromatography 정제, PBS/glycerol buffer 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 245 (N-R-S(p)-L-P) derived from Human ATF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554091 |
Product Specific Information
A suggested positive control for IHC is human breast carcinoma.
Target Information
This gene encodes a transcription factor originally identified as a mammalian DNA-binding protein that binds a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also characterized as cAMP-response element binding protein 2 (CREB-2).
It belongs to a family of DNA-binding proteins including AP-1, CREBs, and CREB-like proteins. These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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