Thermo Fisher Scientific CD14 Monoclonal Antibody (UCHM1)
CD14 단백질을 인식하는 UCHM1 클론의 마우스 단클론 항체입니다. 인간 및 여러 영장류 시료에 반응하며, IHC(F), ICC/IF, Flow Cytometry, IP 등 다양한 응용에 적합합니다. Protein G로 정제된 액상 제품으로, 4°C 또는 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Fish, Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UCHM1 |
| Immunogen | Human thymocytes followed by peripheral blood mononuclear cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955080 |
Product Specific Information
- Not suitable for use in immunohistochemistry (paraffin)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
CD14 is a 55 kDa GPI-anchored glycoprotein constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils.
It functions as a multifunctional lipopolysaccharide (LPS) receptor and is released into serum as both secreted and enzymatically cleaved forms.
CD14 binds LPS in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute-phase serum protein.
The soluble form (sCD14) can distinguish structural differences between LPS molecules and contributes to neutralization of serum lipopolysaccharides.
Additionally, CD14 can bind apoptotic cells and influence allergic, inflammatory, and infectious processes.
Alternative splicing results in multiple transcript variants encoding the same CD14 isoform.
Diseases associated with CD14 dysfunction include Mycobacterium chelonae infection and croup.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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