Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53)
CD33 단백질을 표적하는 WM53 클론의 Mouse IgG1 단일클론 항체. Flow cytometry, IHC, WB, IP 등 다양한 응용 가능. 인간 AML 세포 유래 면역원 사용. 비결합형 액상 형태로 1 mg/mL 농도 제공. 연구용으로만 사용.
- 카탈로그번호
- MA133439
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53)
Thermo Fisher Scientific CD33 Monoclonal Antibody (WM53)
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:50–1:100 | |
| Flow Cytometry (Flow) | 1:10–1:50 | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | WM53 |
| Immunogen | Human AML cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1955246 |
Product Specific Information
- For flow cytometry, use 10 µL of the suggested working dilution to label 10⁶ cells.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family.
It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies.
These ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface.
CD33 is expressed on cells of myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces.
It is a therapeutic target for acute myeloid leukemia and is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells.
CD33 is also expressed on peripheral monocytes and serves as a useful marker for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.