Thermo Fisher Scientific Phospho-FOXO4 (Ser197) Recombinant Superclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, and Dog.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.

While functionally similar to polyclonal antibodies—recognizing multiple epitope sites and providing higher detection sensitivity for low-abundance targets—a recombinant rabbit Superclonal™ antibody has a defined mixture of light and heavy chains, ensuring reproducibility between lots.

Note: Formerly called “Recombinant polyclonal antibody,” now rebranded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.

Target Information

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. Also known as AFX1 or MLLT7, FOXO4 belongs to the O class of forkhead/winged helix transcription factors along with FOXO1, FOXO3, and FOXO6.

FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Phosphorylation of FOXO4 by Akt on specific Ser/Thr residues promotes its interaction with 14-3-3 proteins and subsequent nuclear export.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.