Thermo Fisher Scientific MEP1B Monoclonal Antibody (289731)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

8-25 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

289731

Immunogen

Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B Thr23-Ser293 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEP1B,uniProtId:Q16820-1,ncbiNodeId:9606,antigenRange:23-293,antigenLength:701,antigenImageFileName:MA5-23991_MEP1B_Q16820-1_Rat.svg,antigenImageFileNamePDP:MA5-23991_MEP1B_Q16820-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607663

Product Specific Information

This antibody detects the pro form of human or mouse Meprin beta Subunit/MEP1B in Western blots. This antibody does not react with the mature form.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.