Thermo Fisher Scientific MEP1B Monoclonal Antibody (289731)
Human 및 Mouse MEP1B 단백질의 pro form을 특이적으로 검출하는 Rat monoclonal antibody. Western blot 및 IHC(P) 실험에 적합하며, Protein A/G로 정제된 Lyophilized 형태. PBS buffer와 trehalose 포함, -20°C에서 보관.
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 289731 |
| Immunogen | Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B (Thr23–Ser293) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607663 |
Product Specific Information
This antibody detects the pro form of human or mouse Meprin beta Subunit/MEP1B in Western blots.
It does not react with the mature form.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Meprins are multidomain zinc metalloproteases highly expressed in mammalian kidney, intestinal brush border membranes, leukocytes, and certain cancer cells.
They hydrolyze various peptide and protein substrates and are implicated in cancer and intestinal inflammation.
Mature meprins are oligomers of separately encoded alpha and/or beta subunits:
- Homooligomers of alpha subunit are secreted.
- Oligomers containing the beta subunit are plasma membrane-bound.
The MEP1B gene encodes the beta subunit.
Targeted disruption in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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