Thermo Fisher Scientific CD11c Monoclonal Antibody (118/A5), eBioscience
인간 CD11c를 인식하는 마우스 단클론 항체로, IHC(F) 및 IHC(P)에 사용 가능. 액상형, 0.5 mg/mL 농도, PBS(pH 7.2) 버퍼에 0.09% sodium azide 포함. 4°C 보관, 높은 순도와 낮은 응집도 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 118/A5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865423 |
Available Formats
- Alexa Fluor 700
- Alexa Fluor Plus 555
- Alexa Fluor Plus 594
- Biotin
- Custom conjugation available upon request
Product Specific Information
The monoclonal antibody 118/A5 recognizes human CD11c, a 150 kD type I transmembrane protein also known as integrin alpha X.
Integrins are heterodimeric integral membrane proteins composed of alpha and beta chains involved in cell adhesion.
The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with distinct alpha subunits (CD11a, CD11b, CD11c).
The CD11c/CD18 complex is expressed on dendritic cells (especially type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells.
CD11c is also expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
It plays a role in adhesion and CTL killing through interactions with CD54, iC3b, and fibrinogen.
Applications Reported:
- Immunohistochemical staining of frozen tissue sections
- Immunohistochemical staining of formalin-fixed paraffin-embedded tissue sections
- Microscopy
Applications Tested:
This antibody has been tested by immunohistochemistry of formalin-fixed paraffin-embedded human tissue using low or high pH antigen retrieval and can be used at ≤5 µg/mL.
Optimal dilution should be determined by the user for each assay.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD11, along with CD18, forms a heterodimer adhesion molecule.
- CD11a: Expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils, and eosinophils.
- CD11b: Expressed by monocytes, macrophages, NK cells, some B and T cells, and granulocytes.
- CD11c: Expressed in monocytes, macrophages, NK cells, some granulocytes, and subsets of lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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