Thermo Fisher Scientific Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
IRE1α 단백질의 Ser724 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS 기반 완충액에 20% 글리세롤 및 1% BSA 포함. 세포 스트레스 신호전달 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human IRE1 alpha (phospho Ser724). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.18 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901951 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
ERN1 serine/threonine kinase (also known as endoplasmic reticulum to nucleus signaling 1, IRE1α) is a human homologue of the yeast Ire1 gene product.
It possesses intrinsic kinase and endoribonuclease activity and plays a key role in ER-based stress signaling.
ERN1 regulates IRE1 proteolysis in mammalian cells and is critical for extraembryonic cell function essential for fetal viability.
IRE1 acts as a sensor of unfolded proteins in the ER, initiating signaling to the nucleus by splicing XBP1 mRNA, converting it into a potent unfolded-protein response transcriptional activator.
Null mutants are viable, but IRE1 is essential for survival under ER stress conditions. Dominant-negative forms of IRE1p do not affect normal cells but induce apoptosis under unfolded protein stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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