Thermo Fisher Scientific MADD Polyclonal Antibody
MADD 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 마우스 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 버퍼에 보관되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of mouse MADD. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.39 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2901950 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF.
MADD (mitogen activated protein (MAP)-kinase activating death domain protein) associates with the death domain of TNFR1 through its own C-terminal death domain, which is critical for TNFR1 signal generation.
Overexpression of MADD activates MAP kinases ERK and JNK, and induces phosphorylation of cytosolic phospholipase A2.
This suggests that MADD links TNF signaling with MAP kinase activation and arachidonic acid release.
MADD shares 98% homology with DENN (differentially expressed in neoplasmic vs. normal cells), a substrate for JNK3 involved in hypoxia and stress-induced signaling.
It also exhibits 93% sequence conservation with Rab3 GDP/GTP exchange protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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