Thermo Fisher Scientific MADD Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Centrifuge briefly prior to opening.

Target Information

Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF.
MADD (mitogen activated protein (MAP)-kinase activating death domain protein) associates with the death domain of TNFR1 through its own C-terminal death domain, which is critical for TNFR1 signal generation.
Overexpression of MADD activates MAP kinases ERK and JNK, and induces phosphorylation of cytosolic phospholipase A2.
This suggests that MADD links TNF signaling with MAP kinase activation and arachidonic acid release.
MADD shares 98% homology with DENN (differentially expressed in neoplasmic vs. normal cells), a substrate for JNK3 involved in hypoxia and stress-induced signaling.
It also exhibits 93% sequence conservation with Rab3 GDP/GTP exchange protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.