Thermo Fisher Scientific CD48 (soluble) Monoclonal Antibody (OX-78)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:50–1:100
• Publications: View 1 publication

Immunoprecipitation (IP)

• Tested Dilution: —
• Publications: View 1 publication

Product Specifications

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Rat anti-Mouse CD48 antibody, clone OX-78 recognizes murine CD48 antigen, also known as BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2.

Target Information

CD48 (Blast-1) belongs to the CD2 subset of the immunoglobulin superfamily that includes CD2, CD58, CD84, CD150, CD229, CD244, and others. These molecules mediate homotypic or heterotypic adhesion through interactions among members of the Ig family.
CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2. The 2B4–CD48 interaction among NK and NK-T cells regulates cell proliferation.
Signaling through CD48 results in eosinophil activation, and its expression increases in several infectious diseases. CD48 is strongly expressed on lymphocytes and monocytes, weakly on granulocytes, but absent on platelets, fibroblasts, epithelium, and endothelium.
CD48 is a marker for detecting GPI anchoring structure defects in patients with paroxysmal nocturnal hemoglobinuria (PNH) and may serve as a pharmacological target for allergic airway diseases such as allergic rhinitis and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.