Thermo Fisher Scientific CD62E/CD62P Monoclonal Antibody (1.2B6)
CD62E/CD62P 단클론 항체(1.2B6)는 인간 및 돼지 반응성을 가지며, E-selectin과 P-selectin을 인식합니다. 다양한 응용(ELISA, WB, IHC, Flow 등)에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 염증 반응 연구 및 세포 부착 기전 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1–10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
| ELISA | 10 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Pig |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1.2B6 |
| Immunogen | Human E-Selectin (ELAM-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_929204 |
Additional Formats:
Product Specific Information
MA1-80430 inhibits neutrophil adhesion to E-selectin and to P-selectin.
Non-reducing conditions are recommended for Western blot applications.
A suggested positive control is human tonsil.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Mouse anti-Human CD62E/CD62P antibody, clone 1.2B6 recognizes the human CD62E and CD62P cell surface antigens.
Target Information
CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin (ELAM-1).
It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and absent on leukocytes.
CD62E contributes to leukocyte rolling and adhesion on endothelial surfaces, essential for extravasation into tissues.
CD62P is a 140 kDa membrane glycoprotein (PADGEM/GMP-140), expressed on platelets, megakaryocytes, and epithelium.
It mediates adhesive interactions of neutrophils and monocytes with endothelium during inflammation and platelet activation.
The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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