Thermo Fisher Scientific GCAP2 Monoclonal Antibody (A1)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

ELISA

• Tested Dilution: Assay-dependent

Publications

• 1 publication available

Product Specifications

Product Specific Information

MA1-725 detects GCAP-2 from bovine samples. This antibody is specific for GCAP-2 and does not react with other isotypes.
MA1-725 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~23 kDa protein representing GCAP-2 protein in bovine samples.
The MA1-725 immunogen is bacterial expressed full length GCAP-2.

Target Information

Guanylate cyclase-activating proteins (GCAPs) are calcium-binding proteins that belong to the calmodulin superfamily.
GCAPs without calcium are responsible for activation of photoreceptor guanylate cyclase during light adaptation.
Studies have shown that the addition or subtraction of Ca²⁺ results in major conformational changes and the activation/deactivation of GCAP-1 and GCAP-2.
Both GCAP-1 and GCAP-2 act on guanylate cyclase similarly and share approximately 50% homology.
GCAP-1 is predominantly localized in the photoreceptor outer segments, while GCAP-2 is found in retina samples.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.