Thermo Fisher Scientific MTDH Monoclonal Antibody (OTI1D3), TrueMAB
MTDH 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, Western blot에 적합합니다. 인간 시료 반응성이 있으며, 동결건조 상태로 제공됩니다. 재구성 후 약 1 mg/mL 농도로 사용 가능하며, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 70–582 of human MTDH produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Metadherin (MTDH, LYRIC) is a metastasis adhesion protein associated with tight junction proteins ZO-1 and occludin in polarized epithelial cells. It is not a structural component but is recruited during tight junction maturation.
Metadherin is overexpressed in breast cancer tissue and xenografts, with low expression in normal breast tissue. It binds to lung vasculature—a common site of breast cancer metastasis—via a C-terminal extracellular domain segment. Blocking this domain or inhibiting metadherin with siRNA has been reported to reduce breast cancer metastasis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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