Thermo Fisher Scientific ERBB3 Monoclonal Antibody (OTI3E10), TrueMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family.
ErbB3 is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12 (12q13) and encodes a 160/180 kDa glycoprotein.
It forms heterodimers with other EGF receptor family members, activating pathways that lead to cell proliferation or differentiation.
Alternate splice variants include a secreted isoform that modulates activity of the membrane-bound form.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.