Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI2B5), TrueMAB

Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI2B5), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin conjugate available (Product # TA700052)
• Custom conjugation service available

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where expression is often reduced or undetectable.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between ACY1 and ABHD14A. A pseudogene is found on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.