Thermo Fisher Scientific CD34 Monoclonal Antibody (OTI8F11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It functions as a stem cell marker, with reversible expression on human hematopoietic stem cells. CD34 may act as a receptor mediating endocytosis and regulating adhesion, differentiation, and proliferation of hematopoietic and progenitor cells. It likely plays a role in cell adhesion to the bone marrow extracellular matrix or stromal cells and may serve as a scaffold for glycan attachment, facilitating interactions with lectins. The intracellular domain can be phosphorylated by activated protein kinase C, suggesting a signaling role.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.