Thermo Fisher Scientific KIT Monoclonal Antibody (OTI14B1), TrueMAB
Human KIT 단백질(aa 27-308)을 인식하는 OTI14B1 클론의 mouse monoclonal antibody. Western blot 및 IHC(P) 검증 완료. 무보존제, Lyophilized 형태로 제공되며 재구성 및 conjugation 실험에 적합. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI14B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 27–308 of human KIT produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
KIT (c-KIT) is a proto-oncogene encoding a type III transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). It regulates growth and activation of various hematopoietic and non-hematopoietic cells.
Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.
Activation of c-KIT triggers multiple downstream signaling pathways including Ras/ERK, PI3K, PLC-γ, and JAK/STAT, playing essential roles in hematopoiesis, stem cell maintenance, and gametogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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