Thermo Fisher Scientific CAP57 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI is a bactericidal compound present in polymorphonuclear cells (PMN) and in lower levels in eosinophils. It binds with high affinity to the lipid A region of lipopolysaccharides (LPS) in gram-negative bacterial membranes, leading to multiple anti-infective activities:

• Cytotoxicity via sequential damage to bacterial membranes
• Neutralization of gram-negative bacterial LPS
• Opsonization of bacteria to enhance phagocytosis by neutrophils

BPI may influence LPS-triggered airway diseases, as airway epithelial cells constitutively express BPI. Inflammation induced by LPS may contribute to rapid airflow decline, a severe complication in hematopoietic cell transplantation.
A 21 kDa recombinant fragment, rBPI21, has shown survival benefits against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen pneumolysin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.