Thermo Fisher Scientific JIP3 Polyclonal Antibody
JIP3 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. IHC(P)에서 4–6 µg/mL로 사용 가능하며, 인간 JIP3의 두 isoform을 인식. 액상 형태로 제공되며, TBS(pH 7.3) 버퍼에 0.5% BSA 포함. 연구용으로만 사용.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence MEIQMDEGGGVV-C (aa 2–13) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932720 |
Product Specific Information
- This antibody is expected to recognize both reported human isoforms of JIP3 (NP_055948.2 and NP_001035529.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
c-Jun NH2-terminal kinases (JNKs) are members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to UV light, leading to phosphorylation of c-Jun at Ser 63 and Ser 73, resulting in transcriptional activation.
JIP-1 (JNK interacting protein-1) acts as a cytoplasmic inhibitor of JNK, retaining JNK in the cytoplasm and inhibiting JNK-regulated gene expression.
Multiple JIP family members, including JIP-1b, JIP-1c (IB-1), JIP-2a, JIP-2b, and JIP-3, have been identified in brain tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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