Thermo Fisher Scientific MSLN Monoclonal Antibody (OTI8H7), TrueMAB
Human MSLN 단백질(aa 270-493)을 인식하는 Mouse IgG1 단클론 항체로 Western blot 및 Luminex 분석에 사용 가능. 무보존제, 동결건조 형태이며 재구성 후 1 mg/mL 농도로 실험에 활용. 암 조직에서 높은 발현을 보이는 Mesothelin 연구용에 적합.
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Thermo Fisher Scientific MSLN Monoclonal Antibody (OTI8H7), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8H7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 270–493 of human MSLN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Mesothelin (MSLN) is a GPI-anchored cell-surface glycoprotein expressed by mesothelial cells and overexpressed in various cancers including mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas.
It is cleaved to produce megakaryocyte potentiating factor (MPF), which stimulates megakaryocyte colony formation.
Aberrant expression of Mesothelin and MPF is associated with tumorigenesis, promoting cancer cell proliferation, migration, and metastasis.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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