Thermo Fisher Scientific beta Amyloid Monoclonal Antibody (APP/3667)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Alzheimer’s disease brain, Amyloidosis
• Cellular Location: Membrane; clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) in a two-step process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, cleaves the intra-membrane site of beta APP to produce amyloid beta peptide.
Nicastrin, a transmembrane glycoprotein associated with presenilins, binds to the carboxyl-terminus of beta APP and modulates amyloid beta production.
Abeta forms extracellular filamentous deposits in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are also found in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy), and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)