Thermo Fisher Scientific beta Amyloid Monoclonal Antibody (APP/3667)
Human beta Amyloid 단백질을 인식하는 APP/3667 클론의 mouse monoclonal antibody. Alzheimer’s disease 연구용으로 적합하며, IHC(P) 검증 완료. Protein A로 정제된 액상 형태로 4°C 보관.
- 카탈로그번호
- 351-MSM7-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific beta Amyloid Monoclonal Antibody (APP/3667)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | APP/3667 |
| Immunogen | Recombinant fragment (around aa500–700) of human APP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Alzheimer’s disease brain, Amyloidosis
- Cellular Location: Membrane; clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) in a two-step process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, cleaves the intra-membrane site of beta APP to produce amyloid beta peptide.
Nicastrin, a transmembrane glycoprotein associated with presenilins, binds to the carboxyl-terminus of beta APP and modulates amyloid beta production.
Abeta forms extracellular filamentous deposits in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are also found in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy), and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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