Thermo Fisher Scientific Phospho-NMDAR2B (Ser1480) Polyclonal Antibody
Phospho-NMDAR2B (Ser1480) 폴리클로날 항체로, NMDA 수용체의 인산화 상태 연구에 적합합니다. Western blot에 최적화되어 있으며, 마우스 및 랫트에 반응합니다. 고순도 친화 크로마토그래피 정제, -20°C 보관, 방부제 무첨가.
- 카탈로그번호
- PA14733
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-NMDAR2B (Ser1480) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1480 of rat GRIN2B conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1090548 |
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus based on 100% sequence homology.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to learning and memory.
They play a role in neuronal development and are implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression is observed in aged, memory-impaired animals.
Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunctions are linked to epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.