Thermo Fisher Scientific Phospho-NMDAR2B (Ser1480) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• View 2 publications

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus based on 100% sequence homology.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to learning and memory.
They play a role in neuronal development and are implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression is observed in aged, memory-impaired animals.
Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunctions are linked to epileptic encephalopathy and autosomal dominant 6-related mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.