Thermo Fisher Scientific SOCS5 Polyclonal Antibody
SOCS5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 실험에 적합합니다. Human에 대해 검증되었으며 Rat, Pig 등 다양한 종에 예측 반응성을 보입니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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- PA521600
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide containing a sequence corresponding to a region within amino acids 1–42 of SOCS5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_11151963 |
Product Specific Information
- Recommended positive controls: Molt-4, NT2D1, PC-3, mouse testis
- Predicted reactivity: Rat (100%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 (SH2) domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). Eight members of the SOCS family have been identified: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
Each SOCS protein consists of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form part of a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. SOCS gene transcription occurs rapidly in response to cytokines, and each member inhibits signaling through distinct mechanisms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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