Thermo Fisher Scientific PSMF1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• View 1 publication

Product Specifications

Product Specific Information

• Recommended positive control: HepG2
• Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of two main subcomplexes: the 20S core and the 19S regulator.

• The 20S core consists of four rings of 28 subunits (two alpha and two beta rings).
• The 19S regulator includes a base (six ATPase and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
  Proteasomes function in an ATP/ubiquitin-dependent, non-lysosomal protein degradation pathway and play a key role in MHC class I peptide processing.
  The PSMF1 gene encodes a protein that inhibits proteasome activation by the 11S and 19S regulators. Alternative transcript variants have been identified.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.