Applied Biosystems™

Converge™ Software

The product includes a Converge server and the software. In order to activate and use the Case Management application with자세히 알아보기

The product includes a Converge server and the software. In order to activate and use the Case Management application with either the NGS or Kinship Analysis modules (described below), the appropriate license must be purchased.

Key features and benefits:
• Analyze NGS data from Precision ID GlobalFiler NGS STR Panel v2, Precision ID mtDNA Whole Genome or Control Region Panels, Precision ID Identity Panel Precision ID Ancestry Panel, or custom Ion AmpliSeq SNP panels
• Conduct routine and complex paternity/kinship analysis
• Centralize and manage forensic data and case information in one place for easy access
• Customize information architecture, data inputs, and parameters to meet the needs of your laboratory

NGS Data Analysis module
The NGS Data Analysis module allows users to analyze STR, SNP, or mtDNA data from Precision ID workflows and is required to generate profiles from the Applied Biosystems Precision ID GlobalFiler NGS STR Panel v2. NGS analysis functionality includes information on STR allele call, STR sequence motifs, SNPs in flanking regions, and the ability to distinguish isometric heterozygotes (alleles of the same fragment length but containing different sequences). These additional sources of allelic diversity may be useful in both mixture analysis and kinship interpretation. With an interface that is similar to that of Applied Biosystems GeneMapper ID-X Software, forensic analysts will be able to quickly evaluate NGS data using familiar process quality values (PQVs) and flags such as allele number (AN), off-ladder allele (OL), peak height ratio (PHR), below stochastic threshold (BST), and control concordance (CC). Preconfigured analysis settings are provided within the NGS module and may be modified by the laboratory as needed. Additionally, full auditing functionality is included for chain of custody requirements. Using the NGS Data Analysis module with the Case Management application allows for simplified comparison of NGS and CE profiles.

For mtDNA analysis with either the Precision ID mtDNA Whole Genome Panel or the Precision ID mtDNA Control Region Panel, the Converge NGS Data Analysis module provides simple, accurate variant calling. The automated mtDNA NGS analysis pipeline integrates various sources of knowledge for mtDNA variation, including phylotree and EMPOP, to provide fine-tuned alignments and variant calls that avoid the pitfalls of standard algorithms. Laboratories interested in more advanced analysis and reporting of mtDNA types can obtain and compare haplotype and haplogroup information, along with quantitative assessments for point and length heteroplasmies. In addition to applying relevant forensic recommendations according to SWGDAM Interpretation Guidelines for Mitochonidrial DNA Analysis (2019), Converge Software also offers enhanced usability features for in-depth sequence analysis using an integrated IGV-light viewer with flexible thresholding and CODIS-formatted exports.

The Converge software NGS module contains analysis parameters for generating reports from the Precision ID Ancestry Panel, Precision ID Identity Panel, or custom Ion AmpliSeq SNP panels. Converge SNP analysis provides a variety of metrics to monitor sequencing quality, including coverage of aligned reads to a hotspot, strand bias, number of reads containing each base at the hotspot, genotype call and quality. Tertiary ancestry analysis consists of generating an estimation of admixture prediction from seven geographical regions: Africa, America, East Asia, Europe, Oceania, South Asia, and Southwest Asia. Analysis can be performed using default population and allele frequency information from the 1000 Genome projects; alternatively, users can designate their own populations and allele frequencies for refined analysis.

Kinship and Paternity module
Kinship and paternity testing present challenges due to the complexity of laboratory workflows and statistical analyses performed. The Converge Kinship and Paternity module integrates with Converge Software and GeneMapper ID-X genotyping software to help enable automated analysis, reporting of routine paternity and other relationship testing cases, and allows for genetic likelihood ratio calculation, as well as reporting. The system is highly configurable to fit specific laboratory workflows, standard operating procedures (SOPs), and analysis parameters. It can also be integrated into an existing laboratory information management system (LIMS) using service-oriented architecture integration points that are built into Converge Software.

Case Management application
Converge Software is designed to increase the efficiency of forensic and relationship DNA testing laboratories through the centralization of data creation, analysis, and storage to a single access point. The Case Management application supports case, subject, genotype profile, and laboratory data management, and allows for automated data transfer and integration with various forensic DNA laboratory systems. The software is highly configurable to fit specific laboratory workflows, not only for analysis parameters, but also for data fields per the laboratory Standard Operating Procedures. In addition, it allows for configuration of the user interface and output reports, and provides features that help ensure data security and integrity. These features are easily accessible through a secured web browser interface under the protection of the laboratory`s own IT department. A variety of software modules can be readily built on the Converge platform to support various forensic applications.

Learn more about Case Management & NGS Analysis license combo >
Learn more about Case Management & Kinship & Paternity Analysis license combo >
Learn more about training opportunities for the Converge Software >

사양

제품라인CONVERGE™

시작 물질DNA

제품 유형Converge Software

수량Each

배송 조건Room Temperature

Unit SizeEach