Thermo Fisher Scientific FOXO4 Polyclonal Antibody
FOXO4 단백질을 인식하는 염소 폴리클로날 항체로, Western blot에 적합합니다. 합성 펩타이드(aa 459-472)를 면역원으로 사용하였으며, Human 시료에 반응합니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EAASQDRMPQDLD) corresponding to the internal amino acids of FOXO4 (aa 459–472) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980263 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia, Trithorax Homolog, Translocated To, 7). FOXO4 belongs to the O class of forkhead/winged helix family of transcription factors along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. Activation of another downstream target, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues, mediating its binding to 14-3-3 and subsequent nuclear export.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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