Thermo Fisher Scientific KCNQ5 Polyclonal Antibody
KCNQ5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC에 사용 가능. 인간 및 마우스 시료에 반응하며, 내부 펩타이드를 면역원으로 제작. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from internal region of human KCNQ5 (Kv7.5) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: KCNQ5.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. There are five known KCNQs (KCNQ1–5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that substantially increase the M-current. Inhibition of M-current controls neuron excitability and responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy. Voltage-dependent potassium channels regulate resting membrane potential and modulate excitability of electrically active cells. These channels are typically tetrameric and can interact with auxiliary subunits that modify current properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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