Thermo Fisher Scientific Pannexin 1 Polyclonal Antibody
Pannexin 1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. WB, IHC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제됨. PBS 버퍼에 0.1% sodium azide 포함, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 7 publications |
| Immunohistochemistry (IHC) | 2–4 µg/mL | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), identical to rat and human sequences. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532253 |
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins that are highly conserved among invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels.
Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is more distantly related. PANX1 forms mechanosensitive ATP-permeable channels between adjacent cells and within the endoplasmic reticulum. It may act as a Ca²⁺-leak channel to regulate ER Ca²⁺ homeostasis and influence neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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