Thermo Fisher Scientific Pannexin 1 Polyclonal Antibody
Thermo Fisher Scientific의 Pannexin 1 Polyclonal Antibody는 Mouse 및 Rat에 반응하며, Western blot 및 IHC 등에 사용 가능. Rabbit IgG 기반의 비결합 액상 항체로 항원 친화 크로마토그래피로 정제됨. 연구용으로 ER Ca2+ 조절 및 세포 간 ATP 통로 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | View 5 publications |
| Immunohistochemistry (IHC) | 2–4 µg/mL | View 3 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), identical to rat and 92% homologous to human sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2532255 |
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins that are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins forming large pore ion and metabolite-permeable channels.
Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is more distantly related.
PANX1 functions as a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. It may act as a Ca²⁺ leak channel regulating ER Ca²⁺ homeostasis and neural stem/progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- 항원 구조 이미지: 488100_Pannexin_1_Q9JIP4-1_Rabbit.svg
- 항원 PDP 이미지: 488100_Pannexin_1_Q9JIP4-1_Rabbit_PDP.jpeg
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