Thermo Fisher Scientific Connexin 31.1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The connexin family of proteins form hexameric complexes, called connexons, that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains; the transmembrane and extracellular regions. Connexin 31.1 (Cx31.1 or Gap junction beta-5 protein) is a 271 amino acid protein predominantly expressed in skin, with lower expression in testis. Expression of connexin 31.1 is required for normal placental development in mice. Down-regulation of the connexin 31.1 gene correlates with head and neck squamous cell carcinomas (HNSCC), suggesting it may be a potential therapeutic target.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.