Thermo Fisher Scientific TLR7 Polyclonal Antibody
TLR7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. Human과 Mouse 반응성이 있으며, 고순도 Protein G 정제 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH, corresponding to residues Y(465)FRYDKYARSCRFKNKEAS(483) of human TLR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561735 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 leucine-rich repeats (LRR) and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity.
TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies close to TLR8.
TLR7 acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion, and inflammatory response. It recognizes pathogen-associated molecular patterns (PAMPs) and mediates cytokine production necessary for effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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