Thermo Fisher Scientific TAB1 Monoclonal Antibody (2D3)
TAB1 단백질을 인식하는 마우스 단클론 항체(2D3)로, Western blot과 ELISA에 사용 가능. 인간 TAB1(1-300) 재조합 단백질로부터 유래. 2 mg/mL 액상 형태로 제공되며, -20°C에서 보관. A431 세포를 양성 대조군으로 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| ELISA | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D3 |
| Immunogen | Recombinant human protein purified from E. coli (His-TAB1(1–300)) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2140402 |
Product Specific Information
A suggested positive control for this product is A431 cells.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminus can act as a dominant-negative inhibitor of TGF beta, suggesting that TAB1 functions as a mediator between TGF beta receptors and TAK1. It can also interact with and activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 responses to various stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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