Thermo Fisher Scientific SUMO2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human SUMO2 protein. Validated for WB, IHC(P), and ICC/IF. Suitable for detecting SUMO2 in post-translational modification studies. Supplied as liquid, antigen affinity purified, and stored in PBS with glycerol.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SUMO2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856557 |
Product Specific Information
Immunogen sequence: TDKPAQLEME DEDTIDVFQQ PTGGV
Target Information
SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family. This family functions similarly to ubiquitin, binding target proteins as part of a post-translational modification system. Unlike ubiquitin, which targets proteins for degradation, SUMO2 participates in various cellular processes including nuclear transport, transcriptional regulation, apoptosis, and protein stability.
In vertebrates, three SUMO family members exist: SUMO1, SUMO2, and SUMO3. SUMO2 and SUMO3 share functional similarities distinct from SUMO1. SUMO modification sites present in the N-terminal regions of SUMO2 and SUMO3 are used by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric SUMO chains on protein substrates—a property not shared by SUMO1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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