Thermo Fisher Scientific Neuronal-Nuclei (NeuN) (Neuronal Marker) Monoclonal Antibody (NEUN/7167)
NeuN 단백질을 표적하는 Monoclonal 항체로, 인간 시료에서 신경세포 특이적 마커로 사용됩니다. IHC(P) 및 IHC(PFA) 실험에 적합하며, 고순도의 Protein A/G 정제 항체입니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NEUN/7167 |
| Immunogen | Recombinant fragment (around aa1–200) of human RBFOX3 (NeuN) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Fox-3, also known as NEUN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. It is localized to both the nucleus and cytoplasm and is suggested to regulate alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which constitutes over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.
- p53: Maintains genetic integrity by regulating DNA repair and cell death. Loss or malfunction is linked to malignant growth and Li-Fraumeni syndrome.
- BRCA1: Involved in DNA repair and associated with early-onset breast cancer and predisposition to cancers of the ovary, colon, prostate, and fallopian tubes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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