Thermo Fisher Scientific Phospho-DUSP16 (Ser446) Polyclonal Antibody
DUSP16 단백질의 Ser446 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(Paraffin) 실험에 최적화. 인산화 상태 선택적 검출로 신호전달 연구에 적합. 사람, 마우스, 랫트 반응성.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DUSP16 (Accession Q9BY84), corresponding to amino acid residues around phosphorylated Ser446 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817411 |
Product Specific Information
Antibody detects endogenous levels of DUSP16 only when phosphorylated at Ser446.
Target Information
Dual-specificity phosphatases (DUSPs) are a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. They can dephosphorylate both tyrosine and serine/threonine residues.
DUSP16, also known as MKP-7, dephosphorylates MAPK proteins ERK, JNK, and p38 with distinct specificity. MKPs have a conserved C-terminal catalytic domain and an N-terminal Cdc25-like domain. MAPK activation cascades regulate processes such as cellular proliferation, apoptosis, differentiation, and stress responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-106012_DUSP16_Q9BY84-1_Rabbit.svg, PA5-106012_DUSP16_Q9BY84-1_Rabbit_PDP.jpeg)
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