Thermo Fisher Scientific COPG Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal COPG 항체로 Western blot 및 IHC(P) 검증됨. 항원 친화 크로마토그래피로 정제된 액상형 제품이며, 장기 보관 시 -20°C에서 보관 권장. 단백질 수송 및 지질 항상성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COPG. Recombinant protein control fragment (Product # RP-96463) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640060 |
Product Specific Information
Immunogen sequence:
VKQPEKVAAT RQEIFQEQLA AVPEFRGLGP LFKSSPEPVA LTESETEYVI RCTKHTFTNH MVFQFDCTNT LNDQTLENVT VQMEPTE
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which mediate biosynthetic protein transport from the ER through the Golgi to the trans-Golgi network.
The coatomer complex is required for budding from Golgi membranes and is essential for retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), small GTP-binding proteins.
This complex also influences Golgi structural integrity and regulates lipid homeostasis by controlling PLIN2 and PLIN3 presence on lipid droplets and promoting PNPLA2-mediated lipolysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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