Thermo Fisher Scientific CD4 Monoclonal Antibody (UMAB64), UltraMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD4 antigen participates in MHC class II molecule recognition and serves as a co-receptor for HIV. It is primarily expressed in T helper cells but can also be found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression occurs in thymus, lymph nodes, tonsils, spleen, and certain regions of the brain, gut, and other non-lymphoid tissues.
CD4 facilitates early T-cell activation through association with the T-cell receptor complex and Lck kinase and may mediate neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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