Thermo Fisher Scientific PAPD5 Polyclonal Antibody
Human PAPD5 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. RNA polyadenylation 관련 연구용으로 적합.
- 카탈로그번호
- PA561689
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PAPD5. Recombinant protein control fragment (Product #RP-98642) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645197 |
Product Specific Information
Immunogen sequence:
YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGNGVTLI VDTQQLDKCN NNLSEENEAL GKCRSKTSES LSKHSSNSSS GPVS
Antigen sequence identity:
- Mouse: 95%
- Rat: 94%
Target Information
PAPD5 is a terminal nucleotidyltransferase that catalyzes the transfer of ATP and GTP to RNA 3′ poly(A) tails, creating heterogeneous tails that stabilize mRNAs by preventing deadenylation (PubMed:21788334, PubMed:30026317). It functions as a catalytic subunit of a TRAMP-like complex with poly(A) RNA polymerase activity, involved in post-transcriptional quality control. Polyadenylation with short oligo(A) tails is required for exosome-mediated RNA degradation. PAPD5 operates independently of cofactors for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). It is essential for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including SLC2A1/GLUT1 (PubMed:28383716), and plays roles in histone mRNA degradation, sister chromatid cohesion (PubMed:18172165), and 3′ adenylation of microRNA MIR21 and H/ACA box snoRNAs, influencing their stability and degradation (PubMed:25049417, PubMed:22442037). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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