Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI2F8), Biotin, TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:250–1:1,000

Luminex (LUM)

• Tested Dilution: Assay-dependent

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Target Information

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules capable of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. These ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface.

CD33 is expressed on cells of myelomonocytic lineage and binds sialic acid residues in N- and O-glycans on cell surfaces. It serves as a therapeutic target for acute myeloid leukemia and is found on granulocyte and macrophage precursors in the bone marrow, but not on pluripotent stem cells. CD33 is also expressed on peripheral monocytes and is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.

Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.