Thermo Fisher Scientific CD33 Monoclonal Antibody (OTI1E10), Biotin, TrueMAB
인간 CD33 단백질을 인식하는 Mouse IgG1 단클론 항체로, Biotin으로 표지된 TrueMAB 형식입니다. ELISA 및 Luminex 분석에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능하며 급성 골수성 백혈병 등 CD33 관련 연구에 활용됩니다.
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Applications
ELISA
- Tested Dilution: 1:250–1:1,000
Luminex
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E10 |
| Immunogen | Full-length human recombinant CD33 protein produced in HEK293T cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2 for signal regulation. These motifs also mediate ubiquitin-dependent receptor removal from the cell surface.
CD33 is expressed on cells of the myelomonocytic lineage and binds sialic acid residues on N- and O-glycans. It serves as a therapeutic target for acute myeloid leukemia and is found on granulocyte and macrophage precursors in bone marrow, but not on pluripotent stem cells. CD33 is also a marker for peripheral monocytes and useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias.
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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